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Jeuveau vs. Botox: What's the Difference?

Botox vs. Jeuveau has been an ongoing debate in the aesthetics and cosmetic world. Both FDA-approved wrinkle reducing injectables are the fastest way to eliminate those unwanted flaws on the skin, but what is the difference between the two? In this blog we will discuss the similarities and differences between the two neuromodulators and which one might be right for you.

What is a Neuromodulator?

A neuromodulator is a chemical or compound that affects signaling between neurons, or nerve cells. When a neuromodulator is injected directly into a muscle, it blocks certain signals from the nerve cells that cause the muscle to contract. The most popular neuromodulator is Botulinum toxin type A. When injected in minute amounts, it can help treat and prevent wrinkles and fine lines. There are 4 popular injectable treatments all made with Botulinum toxin type A: Botox, Jeuveau, Dysport, and Xeomin. Soon to be the 5th on the market: Daxxify. (Stay tuned for it's release!) All of the wrinkle treatments on the market have minor differences in their formulas, but work essentially the same way.

What is Jeuveau?

Jeuveau is considered the newest neuromodulator on the market as of today, and is made with the same active ingredient: Botulinum toxin type A. FDA-approved in 2019, Jeuveau works the same as the other injectables, but it is made a little differently. The main distinguishing factor is that Jeuveau is made with "Hi-Pure" technology. The Hi-Pure technology involves additional steps such as additional acid precipitation, treatment to remove other proteins, and something called anion exchange chromatography. The very scientific process ensures that the product is much purer and theoretically safer. Jeveau was tested to find side effects (adverse events) on mice and it was found that twice as much Jeveau was required to lead to an adverse event as Botox. (1) The manufacturer of Jeuveau also vacuum-dries the product, instead of freeze-drying it, which is thought to result in a more potent product. (2)

With Jeuveau, patients can see results in as little as 2-3 days, and can last anywhere from 3-6 months.

What is Botox?

Botox is the original neuromodulator. FDA-approved for cosmetic use in 2002, Botox was originally used to treat a medical condition called strabismus (crossed eyes), and blepharospasm (eye twitching). Like Jeuveau, Botox is used to relax or weaken muscles and reduce the appearance of wrinkles and fine lines.

Since its inception, Botox has been to treat the following conditions:

  • neck spasms

  • overactive bladder

  • excessive sweating

  • lazy eye

  • migraines

Botox has since built up a brand name like "Chapstick", it is commonly used as a generic term that encompasses all of the neurotransmitters.

Similarities Between Botox and Jeuveau

Jeuveau and Botox have many similarities. They are both neuromodulators made up of Botulinum toxin type A, used to reduce the appearance of fine lines and wrinkles. Among the other injectables, they both have long track records of efficacy.

Treatment Experience: Both products have the same applications, they are injected directly into the muscle. The procedure for both neurotoxins only takes about 10-15 minutes and pre and post-treatment instructions are practically identical.

Efficacy: Both neuromodulators work the same, and produce similar results. They both weaken or relax the muscle that is injected to correct wrinkles and fine lines.

Differences Between Botox and Jeuveau

While there aren't a ton of differences between the two (both have the same active ingredient), there are a few things you should know before choosing which one is right for you.

Formulation: Botox and Jeuveau use the same active ingredient, but the formulation differs. As mentioned above, Jeuveau takes added steps to remove dangerous proteins and to aid with absorption, also called Hi-Pure technology. This gives Jeuveau an increased ability to act in the area where it is placed without getting into the blood stream. (1) The Hi-Pure technology makes the product potentially safer.

Uses: Both Botox and Jeuveau are excellent for fine lines and wrinkle reduction, however, Botox is approved for both medical and cosmetic uses. Unlike Botox, which has nine other therapeutic uses, Jeuveau is specifically formulated for cosmetic use. It is FDA approved for glabellar lines (frown lines) but can also be used off-label for crow’s feet, brow furrows, and other expression lines by a trained provider. (2)

Cost: As we are all aware, inflation has taken a hold of most product and service pricing, including Botox. The company behind Botox has it's raised prices a couple of times since 2020, making it $12 - $16 a unit in most areas. Evolus, the company behind Jeuveau, has kept steady pricing, making it a more-cost effective product at $9-$12 a unit.

Final Thoughts on Jeuveau vs. Botox

At first glance, the two products are almost identical. Both Botox and Jeuveau are excellent products for correcting wrinkles and fine lines. It really all comes down to your preference and your injector's recommendations.

For a knowledgeable consultation on your options for Botox and Jeuveau injections, book an appointment online or give us a call by using the contact information below. Both of our expert injectors are Board-Certified Physician Assistants, specializing in rejuvenation, anti-aging, laser treatments, and skin care for all skin types.


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(1) Jeuveau #newtox by Evolus in Encino, CA. (n.d.). Retrieved October 19, 2022, from

(2) Churashev, B. (2021, May 12). 9 Things to Know About Jeuveau, BOTOX’s Latest Competitor. Dr. Aboutanos. Retrieved October 19, 2022, from

Jeuveau vs. Botox: What’s the difference? Eternal Dermatology- Fulton MD. (2021, March 15). Eternal Dermatology Columbia MD. Retrieved October 19, 2022, from


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