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The Science Behind PRF

Platelet-Rich Fibrin is a medical and cosmetic procedure that uses your own white blood cells to tighten skin, produce collagen, and enhance skin quality. This blog dives into what PRF is, what it can do for your areas of concern, and who may be an optimal candidate for treatment.

What is PRP?

To define and explain what PRF is, we should mention it's parent procedure: PRP. Platelet-Rich Plasma therapy is a procedure used commonly for injuries such as pain caused by rotator cuff tears, Achilles tendon ruptures, and ACL tears. The procedure starts by drawing your blood and spinning it down in a centrifuge to concentrate the platelets. Platelets, or thrombocytes, are blood cells that carry necessary healing agents and cause the blood to clot. These platelets are injected into the injured or diseased tissue to trigger an increased number of healing cells to the area. PRP has been known to reduce pain and fast track the healing process.

What is PRF?

Platelet-Rich Fibrin is collected by spinning down your blood in a centrifuge at a much slower speed than PRP, allowing for a higher concentration of cells. These cells include white blood cells, platelets, fibrin scaffolding, and Mesenchymal stem cells - which are not found in PRP. Since PRP is spun at a higher speed, it seperates the red blood cells from the white, but it also separates some of the most beneficial cells used in PRF.

How does PRF work?

Both platelets and fibrin are involved in the body's healing process. Fibrin forms in a biological response to an injury anywhere on the body. The platelets circling the blood will bind to a scaffold of fibrin, become "activated", and release growth factors. This triggers the wound healing process by producing collagen, new skin cells, and blood vessels. PRF releases these growth factors over about 7 days, whereas PRP only releases growth factors for a few hours. The growth factors are what stimulate the body to produce collagen and stem cells. Take a look at the video below for a better understanding of what you can expect during you procedure.

How long do the results from PRF last?

Results are usually immediate, but the new volume only lasts anywhere from 1-3 weeks.

However, the released growth factors work long-term and is what increases skin quality, produces collagen, and tightens skin. These results won't be seen for 3-4 months and can last anywhere from 6-12 months. We usually advise our clients to receive two PRF procedures spaced 6-8 weeks apart and then maintain your results with a PRF procedure once a year.

Who is a candidate for PRF?

PRF can be used for acne scars, wrinkles, deflated cheeks, hair restoration, and/or the most common: under-eye hollows. For deep under-eye concerns, we usually will advise our clients to get EZ Gel PRF, which acts more like a natural filler and stays longer than regular PRF. The primary difference between the two is the way the PRF is created. With EZ Gel, there is two vials of blood. One is spun down like regular PRF and then cooled, the other is put into a heating chamber. The two are then combined to create a gel.

PRF Treatment of Before and After Photos:

To book a complimentary consultation or to book your PRF procedure with one of our amazing injectors, click here.

Or call or text 210-774-2850.

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Platelet-rich plasma (PRP) injection: How it works: HSS. Hospital for Special Surgery. (n.d.). Retrieved April 12, 2022, from

Wellness, B. (n.d.). Platelet rich fibrin (PRF) Skin & Hair rejuvenation. Cypress Hormone Replacement Doctor. Retrieved April 12, 2022, from

Serenity MedSpa. (2018, April 2). PRF (platelet-rich fibrin): The Ultimate Blood Concentrate. Serenity MedSpa. Retrieved April 12, 2022, from


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